PDB ID: 4L8M
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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F46 | N-[2-fluoro-5-({9-[2-(morpholin-4-yl)ethoxy]-11-oxo-6,11-dihydrodibenzo[B,E]oxepin-3-yl}amino)phenyl]benzamide | PoSSuM | |||
BOG | Octyl beta-D-glucopyranoside | PoSSuM |
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Download interaction data: 4L8M
Structure summary
Code : | 4L8M PDBj RCSB PDB PDBe | ||||||||||||
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Header : | transferase/transferase inhibitor | ||||||||||||
Title : | Human p38 MAP kinase in complex with a Dibenzoxepinone | ||||||||||||
Release Data : | 2013-10-30 | ||||||||||||
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Authors : | Richters, A., Mayer-Wrangowski, S.C., Gruetter, C., Rauh, D. | ||||||||||||
Keywords : | protein kinase, selective p38 inhibitor, SAR, Dibenzoxepinone derivative, Dibenzoxepinone, transferase-transferase inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.1000 Å ) | ||||||||||||
Citation : |
Metabolically Stable Dibenzo[b,e]oxepin-11(6H)-ones as Highly Selective p38 MAP Kinase Inhibitors: Optimizing Anti-Cytokine Activity in Human Whole Blood.
Baur, B.,Storch, K.,Martz, K.E.
et al.
PubMed: 24131218 |
Reaction
Chain : | A | |||||||||||||
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UniProt : | Q16539 (MK14_HUMAN) | |||||||||||||
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