Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
IPE 3-methylbut-3-enyl trihydrogen diphosphate
MG Magnesium ion
RIS 1-hydroxy-2-(3-pyridinyl)ethylidene bis-phosphonic acid
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 4KQS   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of Farnesyl Pyrophosphate Synthase Mutant (Y204A) Complexed with Mg, Risedronate and Isopentenyl Pyrophosphate
Release Data : 2014-04-30
Compound :
mol_id molecule chains synonym
1 Farnesyl pyrophosphate synthase A FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase
ec: 2.5.1.10, 2.5.1.1
fragment: UNP residues 67-419
mutation: Y204A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: FDPS, FPS, KIAA1293
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: PET 11 Derivative
Authors : Barnett, B.L., Tsoumpra, M.K., Muniz, J.R.C.
Keywords : Isoprene biosynthesis, Lipid synthesis, steroid biosynthesis, Transferase, dimethylallyl pyrophosphate, Isoprenoid Pathway, Cholesterol Synthesis, Bisphosphonates
Exp. method : X-RAY DIFFRACTION ( 1.97 Å )
Citation :

Crystal Structure of Farnesyl Pyrophosphate Synthase Mutant (Y204A) Complexed with Mg, Risedronate and Isopentenyl Pyrophosphate

Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.  et al.
To be Published 

Chain : A
UniProt : P14324 (FPPS_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
dimethylallyl diphosphate + isopentenyl diphosphate = (2E)- geranyl diphosphate + diphosphate 2.5.1.1 PubMed:16684881
-
(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)- farnesyl diphosphate + diphosphate 2.5.1.10 PubMed:16684881
-