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Ligands
Code Name Style Show Link
JPP Piperacillin (open form)
GOL Glycerol
Non-standard Residues
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Glycosylation
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Code : 4KQO   PDBj   RCSB PDB   PDBe
Header : Biosynthetic Protein/Antibiotic
Title : Crystal structure of penicillin-binding protein 3 from pseudomonas aeruginosa in complex with piperacillin
Release Data : 2013-11-06
Compound :
mol_id molecule chains
1 Penicillin-binding protein 3 A,B
Source :
mol_id organism_scientific expression_system
1 Pseudomonas aeruginosa  (taxid:208964) Escherichia coli  (taxid:469008)
strain: PAO1
gene: ftsI, PA4418
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
Authors : Nettleship, J.E., Stuart, D.I., Owens, R.J., Ren, J.
Keywords : PENICILLIN-BINDING PROTEINS, PIPERACILLIN, CELL WALL BIOSYNTHESIS, TRANSPEPTIDASE, OUT PERIPLASMIC MEMBRANE, Biosynthetic Protein-Antibiotic complex
Exp. method : X-RAY DIFFRACTION ( 2.31 Å )
Citation :

Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3.

van Berkel, S.S.,Nettleship, J.E.,Leung, I.K.  et al.
(2013)  Acs Chem.Biol.  8 : 2112 - 2116

PubMed: 23899657
DOI: 10.1021/cb400200h

Chain : A, B
UniProt : G3XD46 (FTSI_PSEAE)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine. 3.4.16.4 HAMAP- Rule:MF_02080
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