Brand  (β version)

PDB ID: 4KPD

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Ligands
Code Name Style Show Link
IPE 3-methylbut-3-enyl trihydrogen diphosphate PoSSuM
MG Magnesium ion PoSSuM
RIS 1-hydroxy-2-(3-pyridinyl)ethylidene bis-phosphonic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 4KPD   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of Human Farnesyl Pyrophosphate Synthase (Y204F) Mutant Complexed with Mg, Risedronate and Isopentenyl Pyrophosphate
Release Data : 2014-04-30
Compound :
mol_id molecule chains synonym
1 Farnesyl pyrophosphate synthase A FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase
ec: 2.5.1.10, 2.5.1.1
fragment: UNP residues 67-419
mutation: Y204F
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: FDPS, FPS, KIAA1293
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: PET 11 Derivative
Authors : Barnett, B.L., Tsoumpra, M.K., Muniz, J.R.C., Walter, R.L.
Keywords : Isoprene biosynthesis, Lipid synthesis, steroid biosynthesis, Transferase, dimethylallyl pyrophosphate, Isoprenoid Pathway, Cholesterol Synthesis, Bisphosphonates
Exp. method : X-RAY DIFFRACTION ( 1.96 Å )
Citation :

Crystal Structure of Human Farnesyl Pyrophosphate Synthase (Y204F) Mutant Complexed with Mg, Risedronate and Isopentenyl Pyrophosphate

Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.  et al.
To be Published 

Reaction

Chain : A
UniProt : P14324 (FPPS_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
isopentenyl diphosphate + dimethylallyl diphosphate = (2E)- geranyl diphosphate + diphosphate 2.5.1.1 PubMed:16684881
-
isopentenyl diphosphate + (2E)-geranyl diphosphate = (2E,6E)- farnesyl diphosphate + diphosphate 2.5.1.10 PubMed:16684881
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:19309137
Binds 2 Mg(2+) ions per subunit.