Brand  (β version)

PDB ID: 4KN1

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Ligands
Code Name Style Show Link
04J Aminopterin PoSSuM
CL Chloride ion PoSSuM
K Potassium ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 4KN1   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Human folate receptor beta (FOLR2) in complex with the antifolate aminopterin
Release Data : 2013-08-07
Compound :
mol_id molecule chains synonym
1 Folate receptor beta A FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP
fragment: UNP residues 24-228
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
gene: FOLR2
expression_system_common: Chinese hamster
expression_system_cell_line: CHO
expression_system_vector_type: plasmid
expression_system_plasmid: pSGHV0
Authors : Wibowo, A.S., Dann III, C.E.
Keywords : Folate Receptor Beta, FOLR2, folate receptor, Folic acid, folates, 5-methyltetrahydrofolate, antifolates, folate-conjugates, GPI-anchored protein on eukaryotic membrane, TRANSPORT PROTEIN, MEMBRANE PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.3010 Å )
Citation :

Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition.

Wibowo, A.S.,Singh, M.,Reeder, K.M.  et al.
(2013)  Proc.Natl.Acad.Sci.USA  110 : 15180 - 15188

PubMed: 23934049
DOI: 10.1073/pnas.1308827110

Reaction

Chain : A
UniProt : P14207 (FOLR2_HUMAN)
Reaction : -