Brand  (β version)

PDB ID: 4KKX

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Ligands
Code Name Style Show Link
AQ3 N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-3-[(2-hydroxyphenyl)amino]-D-alanine PoSSuM
EDO 1,2-ethanediol PoSSuM
F6F 2-{[4-(trifluoromethoxy)benzoyl]amino}ethyl dihydrogen phosphate PoSSuM
NA Sodium ion PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
PGE Triethylene glycol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4KKX   PDBj   RCSB PDB   PDBe
Header : LYASE/LYASE INHIBITOR
Title : Crystal structure of Tryptophan Synthase from Salmonella typhimurium with 2-aminophenol quinonoid in the beta site and the F6 inhibitor in the alpha site
Release Data : 2014-01-01
Compound :
mol_id molecule chains
1 Tryptophan synthase alpha chain A
ec: 4.2.1.20
mol_id molecule chains
2 Tryptophan synthase beta chain B
ec: 4.2.1.20
Source :
mol_id organism_scientific
1 Salmonella enterica subsp. enterica serovar Typhimurium  (taxid:90371)
gene: trpA
expression_system_strain: Escherichia coli
expression_system_cell_line: CB149
expression_system_vector_type: Derivative of pBR322
mol_id organism_scientific
2 Salmonella enterica subsp. enterica serovar Typhimurium  (taxid:90371)
gene: trpB
expression_system_strain: Escherichia coli
expression_system_cell_line: CB149
expression_system_vector_type: Derivative of pBR322
Authors : Hilario, E., Niks, D., Dunn, M.F., Mueller, L.J., Fan, L.
Keywords : Lyase, carbon-oxygen lyase, tryptophan biosynthesis, F6F, allosteric enzyme, 2-aminophenol quinonoid, biosynthesis, aromatic amino acid biosynthesis, pyridoxal phosphate, LYASE-LYASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.7700 Å )
Citation :

Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states.

Niks, D.,Hilario, E.,Dierkers, A.  et al.
(2013)  Biochemistry  52 : 6396 - 6411

PubMed: 23952479
DOI: 10.1021/bi400795e

Reaction

Chain : A
UniProt : P00929
Reaction : -
Chain : B
UniProt : P0A2K1
Reaction : -