Brand  (β version)

PDB ID: 4KH2

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
CL Chloride ion PoSSuM
FIF 2,6-anhydro-5-deoxy-5-fluoro-L-idonic acid PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
Modification
Code Name Show

Structure summary

Code : 4KH2   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal structure of human alpha-L-iduronidase complex with 2-deoxy-2-fluoro-alpha-L-idopyranosyluronic acid fluoride
Release Data : 2013-09-18
Compound :
mol_id molecule chains
1 Alpha-L-iduronidase A,B
ec: 3.2.1.76
fragment: UNP residues 27-653
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Arabidopsis thaliana  (taxid:3702)
gene: IDUA
expression_system_common: Thale cress
expression_system_strain: Cgl1 1
expression_system_vector_type: plasmid
expression_system_plasmid: pARC5s3
Authors : Bie, H., Yin, J., He, X., Kermode, A.R., Goddard-Borger, E.D., Withers, S.G., James, M.N.G.
Keywords : glycoside hydrolase family 39, TIM barrel, beta sandwich, fibronectin III domain, glycosaminoglycans, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.36 Å )
Citation :

Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase.

Bie, H.,Yin, J.,He, X.  et al.
(2013)  Nat.Chem.Biol.  9 : 739 - 745

PubMed: 24036510
DOI: 10.1038/nchembio.1357

Reaction

Chain : A, B
UniProt : P35475 (IDUA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate. 3.2.1.76 PubMed:23959878, PubMed:24036510
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