PDB ID: 4KAK
Hetero Atom Contents
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Color scheme of protein:
Code | Name | Style | Show | Link | |
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NDP | Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate | PoSSuM | |||
06U | 6-ethyl-5-{(3r)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine | PoSSuM | |||
EOH | Ethanol | PoSSuM | |||
CA | Calcium ion | PoSSuM |
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Download interaction data: 4KAK
Structure summary
Code : | 4KAK PDBj RCSB PDB PDBe | ||||||||||||
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Header : | Oxidoreductase/oxidoreductase inhibitor | ||||||||||||
Title : | Crystal structure of human dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3S)-3-[3-methoxy-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006) | ||||||||||||
Release Data : | 2013-10-09 | ||||||||||||
Compound : |
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Authors : | Lamb, K.M., Anderson, A.C. | ||||||||||||
Keywords : | Oxidoreductase, 5, 6, 7, 8-tetrahydrofolate; NADP+; 7, 8-dihydrofolate, Hydride shift, Oxidoreductase-oxidoreductase inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.80 Å ) | ||||||||||||
Citation : |
Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase.
Lamb, K.M.,G-Dayanandan, N.,Wright, D.L.
et al.
PubMed: 24053334 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | P00374 (DYR_HUMAN) | ||||||||
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