Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
G Guanosine-5'-monophosphate
MG Magnesium ion
ZN Zinc ion
GTP Guanosine-5'-triphosphate
Code : 4K98
Header : TRANSFERASE/DNA
Title : Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
Release Data : 2013-05-15
Compound :
mol_id molecule chains synonym
1 Cyclic GMP-AMP synthase A cGAMP synthase, cGAS, m-cGAS, Mab-21 domain-containing protein 1
ec: 2.7.7.-
fragment: C-TERMINAL DOMAIN, UNP residues 147-507
mol_id molecule chains
2 DNA-F D
mol_id molecule chains
3 DNA-R E
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Escherichia coli  (taxid:562)
gene: Mb21d1
mol_id organism_scientific
2
synthetic: yes
other_details: This sequence was synthesized by regular protocol
mol_id organism_scientific
3
synthetic: yes
other_details: This sequence was synthesized by regular protocol
Authors : Gao, P., Wu, Y., Patel, D.J.
Keywords : nucleotidyltransferase fold, TRANSFERASE-DNA complex
Exp. method : X-RAY DIFFRACTION ( 1.94 Å )
Citation :

Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

Gao, P.,Ascano, M.,Wu, Y.  et al.
(2013)  Cell(Cambridge,Mass.)  153 : 1094 - 1107

PubMed: 23647843
DOI: 10.1016/j.cell.2013.04.046

Chain : A
UniProt : Q8C6L5 (CGAS_MOUSE)
Reaction : ATP + GTP = 2 diphosphate + cyclic G-P(2'- 5')A-P(3'-5').