Het-PDB Navi2 (PDB: 4K78)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
CSU	Cysteine-S-sulfonic acid

Glycosylation
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Modification
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Download interaction data: 4K78

Code :

4K78 PDBj RCSB PDB PDBe

Header :

PEPTIDE BINDING PROTEIN/PROTEIN BINDING

Title :

CFTR Associated Ligand (CAL) E317A PDZ domain bound to peptide iCAL36-QDTRL (ANSRWQDTRL)

Release Data :

2014-01-22

Compound :

mol_id	molecule	chains	synonym
1	Golgi-associated PDZ and coiled-coil motif-containing protein	A	CFTR-associated ligand, Fused in glioblastoma, PDZ protein interacting specifically with TC10, PIST
	fragment: PDZ domain mutation: E317A

mol_id	molecule	chains
2	iCAL36-QDTRL peptide	B

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: GOPC, CAL, FIG expression_system_strain: BL21(DE3) RIL expression_system_vector_type: plasmid expression_system_plasmid: pET16b

mol_id	organism_scientific
2
	synthetic: yes

Authors :

Amacher, J.F., Madden, D.R.

Keywords :

PDZ domain, CAL, PIST, FIG, PDZ-peptide complex, CFTR Associated Ligand, CFTR, PEPTIDE BINDING PROTEIN-PROTEIN BINDING complex

Exp. method :

X-RAY DIFFRACTION ( 1.800 Å )

Citation :

Stereochemical Preferences Modulate Affinity and Selectivity among Five PDZ Domains that Bind CFTR: Comparative Structural and Sequence Analyses.

Amacher, J.F.,Cushing, P.R.,Brooks, L. et al.
(2014) Structure 22 : 82 - 93

PDB ID: 4K78