Het-PDB Navi2 (PDB: 4K6I)

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Ligands
Code	Name		Style	Show	Link
9RA	4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid				PoSSuM

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Download interaction data: 4K6I

Code :

4K6I PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

Crystal structure of human retinoid X receptor alpha-ligand binding domain complex with Targretin and the coactivator peptide GRIP-1

Release Data :

2013-11-13

Compound :

mol_id	molecule	chains	synonym
1	Retinoic acid receptor RXR-alpha	A	Nuclear receptor subfamily 2 group B member 1, Retinoid X receptor alpha
	fragment: ligand binding domain, UNP residues 228-458

mol_id	molecule	chains	synonym
2	Nuclear receptor coactivator 2	B	NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2
	fragment: coactivator peptide, UNP residues 686-698

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	strain: P19793 gene: NR2B1, RXRA, RXRA NR2B1 expression_system_vector_type: BL21(DE3)

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes other_details: GRIP-1 from AnaSpec Inc

Authors :

Xia, G., Smith, C.D., Muccio, D.D.

Keywords :

ligand binding domain, cancer, Targretin (bexarotene), TRANSCRIPTION

Exp. method :

X-RAY DIFFRACTION ( 2.10 Å )

Citation :

Defining the Communication between Agonist and Coactivator Binding in the Retinoid X Receptor alpha Ligand Binding Domain.

Boerma, L.J.,Xia, G.,Qui, C. et al.
(2014) J.Biol.Chem. 289 : 814 - 826

PDB ID: 4K6I