Brand  (β version)

PDB ID: 4K11

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Ligands
Code Name Style Show Link
0J9 1-tert-butyl-3-(naphthalen-1-yl)-1h-pyrazolo[3,4-D]pyrimidin-4-amine PoSSuM
Non-standard Residues
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PTR O-phosphotyrosine
Glycosylation
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Structure summary

Code : 4K11   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : The structure of 1NA in complex with Src T338G
Release Data : 2014-04-09
Compound :
mol_id molecule chains synonym
1 Proto-oncogene tyrosine-protein kinase Src A c-Src tyrosine kinase, Proto-oncogene c-Src, pp60c-src, p60-Src
ec: 2.7.10.2
fragment: UNP residues 87-534
mutation: T338G
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: SRC, SRC1
expression_system_common: Fall armyworm
Authors : Eck, M.J., Yun, C.H.
Keywords : 1NA, c-Src, Kinase, Phosphorylation, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

The structure of 1NA in complex with Src T338G

Eck, M.J.,Yun, C.H.
To be Published 

Reaction

Chain : A
UniProt : P12931 (SRC_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:14632929, PubMed:19307596, PubMed:21036157, PubMed:35927303, PubMed:7929427, PubMed:8759729, PubMed:9571170
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[Isoform 1]
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 		2.7.10.2 UniProtKB:Q9WUD9
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[Isoform 2]
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 		2.7.10.2 UniProtKB:Q9WUD9
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[Isoform 3]
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 		2.7.10.2 UniProtKB:Q9WUD9
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