Brand  (β version)

PDB ID: 4JZ1

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Ligands
Code Name Style Show Link
F4D 4,4'-[(3-{[(4-fluorophenyl)sulfonyl]amino}pyridine-2,6-diyl)bis(oxy)]dibenzenecarboximidamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4JZ1   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal Structure of Matriptase in complex with Inhibitor
Release Data : 2014-02-26
Compound :
mol_id molecule chains synonym
1 Suppressor of tumorigenicity 14 protein A Matriptase, Membrane-type serine protease 1, MT-SP1, Prostamin, Serine protease 14, Serine protease TADG-15, Tumor-associated differentially-expressed gene 15 protein
ec: 3.4.21.109
fragment: UNP residues 615-855
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ST14, PRSS14, SNC19, TADG15
expression_system_strain: BL21(DE3)
expression_system_vector_type: pET28a
Authors : Subramanya, H.S., Ravi, B.C., Ashok, K.N., Chakshusmathi, G., Ramesh, K.S.
Keywords : MATRIPTASE, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors

Goswami, R.,Mukherjee, S.,Wohlfahrt, G.  et al.
(2013)  ACS MED.CHEM.LETT.  4 : 1152 - 1157

PubMed: 24900621
DOI: 10.1021/ml400213v

Reaction

Chain : A
UniProt : Q9Y5Y6 (ST14_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position. 3.4.21.109 PubMed:16407223
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