Het-PDB Navi2 (PDB: 4JYI)

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Ligands
Code	Name		Style	Show	Link
FLC	Citrate anion				PoSSuM
JYI	3-chloro-4-[(E)-2-(5,5-dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)ethenyl]benzoic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4JYI

Code :

4JYI PDBj RCSB PDB PDBe

Header :

Transcription/Agonist

Title :

Crystal structure of RARbeta LBD in complex with selective partial agonist BMS641 [3-chloro-4-[(E)-2-(5,5-dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)ethenyl]benzoic acid]

Release Data :

2014-03-19

Compound :

mol_id	molecule	chains	synonym
1	Retinoic acid receptor beta	A,B	RAR-beta, HBV-activated protein, Nuclear receptor subfamily 1 group B member 2, RAR-epsilon
	fragment: Ligand binding domain, UNP residues 176-421

mol_id	molecule	chains	synonym
2	Nuclear receptor coactivator 1	F,G	SRC-1
	ec: 2.3.1.48 fragment: UNP residues 686-698

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: RARB, HAP, NR1B2 expression_system_strain: BL21 DE3 expression_system_vector_type: PLASMID expression_system_plasmid: pET15b

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Nadendla, E.K., Teyssier, C., Germain, P., Delfosse, V., Bourguet, W.

Keywords :

Ligand binding domain, Nuclear hormone receptor, Transcription-Agonist complex

Exp. method :

X-RAY DIFFRACTION ( 1.900 Å )

Citation :

An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor beta (RAR beta , NR1B2) Selective Agonist.

Nadendla, E.,Teyssier, C.,Delfosse, V. et al.
(2015) Plos One 10 : e0123195 - e0123195

PubMed: 25933005
DOI: 10.1371/journal.pone.0123195

Chain :	A, B
UniProt :	P10826 (RARB_HUMAN)
Reaction :	-

Chain :

F, G

UniProt :

Q15788 (NCOA1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)	2.3.1.48	-
	-	-

PDB ID: 4JYI

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