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Ligands
Code Name Style Show Link
FMN Flavin mononucleotide
ORO Orotic acid
SO4 Sulfate ion
DET Undecylamine-N,N-dimethyl-N-oxide
JTU 6-bromo-2-{4-[(2r)-butan-2-yl]phenyl}-3-methylquinoline-4-carboxylic acid
Non-standard Residues
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Code : 4JTU   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of human dihydroorotate dehydrogenase (DHODH) with brequinar analogue
Release Data : 2014-03-26
Compound :
mol_id molecule chains synonym
1 Dihydroorotate dehydrogenase (quinone), mitochondrial A DHOdehase, Dihydroorotate oxidase
ec: 1.3.5.2
fragment: UNP residues 29-395
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: DHODH
Authors : Zhu, L., Zhu, J., Ren, X., Li, H.
Keywords : FMN binding, mitochondria inner membrane, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057

Zhu, L.,Li, H.,Zhu, J.  et al.
To be Published 

Chain : A
UniProt : Q02127 (PYRD_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + a quinone = a quinol + orotate 1.3.5.2 PubMed:8925840
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