PDB ID: 4JLH
Hetero Atom Contents
color scheme of protein:
|Header :||TRANSFERASE/TRANSFERASE INHIBITOR|
|Title :||HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor|
|Release Data :||2013-05-01|
|Authors :||Feng, L., Kvaratskhelia, M.|
|Keywords :||Integrase, CCD, DDE motif, drug resistance, A128T mutation, dimer interface, allosteric inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex|
|Exp. method :||X-RAY DIFFRACTION ( 2.0900 Å )|
|UniProt :||P12497 (POL_HV1N5)|
|Reaction :||Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).