PDB ID: 4JLH
Hetero Atom Contents
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Color scheme of protein:
Code | Name | Style | Show | Link | |
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0L9 | (2s)-[6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl](methoxy)ethanoic acid | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM |
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CAF | S-dimethylarsinoyl-cysteine |
Code | Name | Emphasize |
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Download interaction data: 4JLH
Structure summary
Code : | 4JLH PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE INHIBITOR | ||||||||||||
Title : | HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor | ||||||||||||
Release Data : | 2013-05-01 | ||||||||||||
Compound : |
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Source : |
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Authors : | Feng, L., Kvaratskhelia, M. | ||||||||||||
Keywords : | Integrase, CCD, DDE motif, drug resistance, A128T mutation, dimer interface, allosteric inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.0900 Å ) | ||||||||||||
Citation : |
The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors.
Feng, L.,Sharma, A.,Slaughter, A.
et al.
PubMed: 23615903 |
Reaction
Chain : | A | ||||||||||||||||||||||||
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UniProt : | P12497 (POL_HV1N5) | ||||||||||||||||||||||||
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