Brand  (β version)

color scheme of protein:


interaction residue:


Code Name Link
0L9 (2s)-[6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl](methoxy)ethanoic acid
SO4 Sulfate ion
Modified Residues
Code Name Link
CAF S-dimethylarsinoyl-cysteine
Code : 4JLH
Title : HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor
Release Data : 2013-05-01
Compound :
mol_id molecule chains
1 HIV-1 Integrase catalytic core domain A
mutation: A128T, F185K
Source :
mol_id organism_scientific organism_common expression_system
1 Human immunodeficiency virus type 1  (taxid:11698) HIV-1 Escherichia Coli  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
Authors : Feng, L., Kvaratskhelia, M.
Keywords : Integrase, CCD, DDE motif, drug resistance, A128T mutation, dimer interface, allosteric inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.0900 Å )
Citation :

The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors.

Feng, L.,Sharma, A.,Slaughter, A.  et al.
(2013)  J.Biol.Chem.  288 : 15813 - 15820

PubMed: 23615903
DOI: 10.1074/jbc.M112.443390

Chain : A
UniProt : P12497 (POL_HV1N5)
Reaction : Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).