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Ligands
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04A N,N'-[sulfanediylbis(ethane-2,1-diyl-1,3,4-thiadiazole-5,2-diyl)]bis(2-phenylacetamide)
Non-standard Residues
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Code : 4JKT   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of mouse Glutaminase C, BPTES-bound form
Release Data : 2013-08-14
Compound :
mol_id molecule chains synonym
1 Glutaminase kidney isoform, mitochondrial A,B,C,D GLS
ec: 3.5.1.2
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Escherichia coli  (taxid:562)
gene: Gls, Gls1, Kiaa0838
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a
Authors : Fornezari, C., Ferreira, A.P.S., Dias, S.M.G., Ambrosio, A.L.B.
Keywords : Glutaminase, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.77 Å )
Citation :

Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor.

Ferreira, A.P.,Cassago, A.,Goncalves Kde, A.  et al.
(2013)  J.Biol.Chem.  288 : 28009 - 28020

PubMed: 23935106
DOI: 10.1074/jbc.M113.501346

Chain : A, B, C, D
UniProt : D3Z7P3 (GLSK_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
H2O + L-glutamine = L-glutamate + NH4(+) 3.5.1.2 PubMed:22228304, PubMed:23935106, PubMed:27542409
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