Brand  (β version)

PDB ID: 4JDB

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Ligands
Code Name Style Show Link
FMN Flavin mononucleotide PoSSuM
GOL Glycerol PoSSuM
JDB 5-[2-(7-methoxynaphthalen-2-yl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid PoSSuM
NCO Cobalt hexammine(III) PoSSuM
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Structure summary

Code : 4JDB   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Title : Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-005
Release Data : 2014-02-26
Compound :
mol_id molecule chains synonym
1 Dihydroorotate dehydrogenase (fumarate) A,B DHOD, DHODase, DHOdehase, Dihydroorotate oxidase
ec: 1.3.98.1
Source :
mol_id organism_scientific expression_system
1 Trypanosoma cruzi  (taxid:353153) Escherichia coli  (taxid:562)
strain: CL Brener
gene: PyrD
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET3a
Authors : Inaoka, D.K., Iida, M., Tabuchi, T., Lee, N., Hashimoto, S., Matsuoka, S., Kuranaga, T., Shiba, T., Sakamoto, K., Suzuki, S., Balogun, E.O., Nara, T., Aoki, T., Inoue, M., Honma, T., Tanaka, A., Harada, S., Kita, K.
Keywords : Rossmann Fold, Oxidoreductase, Dihydroorotate/orotate and fumarate/succinate binding, Cytosol, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.8200 Å )
Citation :

Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-005

Inaoka, D.K.,Iida, M.,Tabuchi, T.  et al.
To be Published 

Reaction

Chain : A, B
UniProt : Q4D3W2 (PYRD_TRYCC)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + fumarate = orotate + succinate 1.3.98.1 -
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