PDB ID: 4JBY
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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EDO | 1,2-ethanediol | PoSSuM | |||
FSK | 6-[(1z)-3-fluoro-2-(hydroxymethyl)prop-1-en-1-yl]-1,5-dimethylpyrimidine-2,4(1h,3h)-dione | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM |
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Download interaction data: 4JBY
Structure summary
Code : | 4JBY PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with F-SK78 | ||||||||||||
Release Data : | 2013-03-06 | ||||||||||||
Compound : |
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Authors : | Pernot, L., Novakovic, I., Westermaier, Y., Perozzo, R., Raic-Malic, S., Scapozza, L. | ||||||||||||
Keywords : | DNA synthesis, PET imaging TRACER, ATP binding, nucleotide binding, TRANSFERASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.000 Å ) | ||||||||||||
Citation : |
New thymine derivatives as HSV1-TK ligand for the development of PET imaging tracer
Pernot, L.,Novakovic, I.,Perozzo, R.
et al.
Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo.
Martic, M.,Pernot, L.,Westermaier, Y.
et al.
PubMed: 21623543 A new N-methyl thymine derivative comprising a dihydroxyisobutenyl unit as ligand for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK).
Kristafor, S.,Novakovic, I.,Gazivoda Kraljevic, T.
et al.
PubMed: 21911293 |
Reaction
Chain : | A, B |
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UniProt : | P03176 |
Reaction : | - |