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Ligands
Code Name Style Show Link
9MG 9-methylguanine
EDO 1,2-ethanediol
GTG 7-methyl-guanosine-5'-triphosphate-5'-guanosine
Non-standard Residues
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Glycosylation
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Code : 4J7N   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of mouse DXO in complex with M7GPPPG cap
Release Data : 2013-03-27
Compound :
mol_id molecule chains synonym
1 Protein Dom3Z A Dom-3 homolog Z, DXO
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Escherichia coli  (taxid:562)
gene: Dom3z, Ng6
Authors : Kilic, T., Chang, J.H., Tong, L.
Keywords : Decapping, 5'-3' exoribonuclease, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.50 Å )
Citation :

A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing.

Jiao, X.,Chang, J.H.,Kilic, T.  et al.
(2013)  Mol.Cell  50 : 104 - 115

PubMed: 23523372
DOI: 10.1016/j.molcel.2013.02.017

Chain : A
UniProt : O70348 (DXO_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'- end phospho-ribonucleoside in mRNA + H(+) + NAD(+) - PubMed:28283058, PubMed:32374864
left-to-right PubMed:28283058
a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O = a 5'- end phospho-ribonucleoside in snoRNA + H(+) + NAD(+) - PubMed:28283058
left-to-right
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside- ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphospho- guanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+) - PubMed:23523372
left-to-right
a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+) - PubMed:32374864, PubMed:32432673
left-to-right PubMed:32432673
a 5'-end CoA-ribonucleoside in mRNA + H2O = 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+) - PubMed:32374864, PubMed:32432673
left-to-right PubMed:32432673