Brand  (β version)

PDB ID: 4J4B

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Ligands
Code Name Style Show Link
NAI 1,4-dihydronicotinamide adenine dinucleotide PoSSuM
NA Sodium ion PoSSuM
MG Magnesium ion PoSSuM
0TF N~6~-D-ornithyl-L-lysine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4J4B   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : PylD in complex with L-lysine-Ne-D-ornithine and NADH
Release Data : 2013-06-12
Compound :
mol_id molecule chains
1 PylD A,B
ec: 1.4.1.-
Source :
mol_id organism_scientific expression_system
1 Methanosarcina barkeri  (taxid:269797) Escherichia coli  (taxid:469008)
strain: Fusaro
gene: Mbar_A0835
expression_system_strain: BL21(DE3)
expression_system_vector_type: pET28b
Authors : Quitterer, F., Beck, P., Bacher, A., Groll, M.
Keywords : Pyrrolysine, 22nd Amino Acid, Biosynthesis, Rossmann Fold, Dehydrogenase, NADH, oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD).

Quitterer, F.,Beck, P.,Bacher, A.  et al.
(2013)  Angew.Chem.Int.Ed.Engl.  52 : 7033 - 7037

PubMed: 23720358
DOI: 10.1002/anie.201301164

Reaction

Chain : A, B
UniProt : Q46E80 (PYLD_METBF)
Reaction: EC: Evidence:
Physiological Direction:
(3R)-3-methyl-D-ornithyl-N(6)-L-lysine + NAD(+) = L- pyrrolysine + NH4(+) + NADH + 2 H(+) - PubMed:24916332
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