Brand  (β version)

PDB ID: 4J1W

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Ligands
Code Name Style Show Link
FE2 Fe (II) ion PoSSuM
FFQ [(1r)-1-hydroxypropyl]phosphonic acid PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 4J1W   PDBj   RCSB PDB   PDBe
Header : METAL BINDING PROTEIN
Title : Crystal Structure of Fe(II)-HppE with alternative substrate (R)-1-HPP
Release Data : 2013-04-03
Compound :
mol_id molecule chains
1 Epoxidase A,B,C
fragment: Metal and substrate binding domains (UNP Residues 1-198)
Source :
mol_id organism_scientific expression_system
1 Streptomyces wedmorensis  (taxid:43759) Escherichia coli  (taxid:562)
gene: fom4
expression_system_strain: B834(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pPL001
Authors : Drennan, C.L., Dey, M.
Keywords : Hydroxypropylphosphonic acid epoxidase, 1, 2-phosphono migration, mononuclear non-heme iron enzyme, metal binding protein, cupin fold, phosphono migration
Exp. method : X-RAY DIFFRACTION ( 2.72 Å )
Citation :

Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction.

Chang, W.C.,Dey, M.,Liu, P.  et al.
(2013)  Nature  496 : 114 - 118

PubMed: 23552950
DOI: 10.1038/nature11998

Reaction

Chain : A, B, C
UniProt : Q56185 (HPPE_STRWE)
Reaction: EC: Evidence:
Physiological Direction:
(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)- epoxypropylphosphonate + 2 H2O 1.11.1.23 PubMed:16015285
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