Het-PDB Navi2 (PDB: 4IY5)

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Ligands
Code	Name	Link
CL	Chloride ion	PoSSuM
CX5	Piperidin-1-yl(quinoxalin-6-yl)methanone	PoSSuM
GLU	Glutamic acid	PoSSuM
GOL	Glycerol	PoSSuM
SO4	Sulfate ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4IY5

Code :

4IY5 PDBj RCSB PDB PDBe

Header :

MEMBRANE PROTEIN

Title :

Crystal structure of the glua2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and CX516 at 2.0 A resolution

Release Data :

2013-10-09

Compound :

mol_id	molecule	chains	synonym
1	Glutamate receptor 2	A,B	GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2
	fragment: Ligand binding domain, UNP RESIDUES 413-527, 653-796 mutation: L94Y, N242S

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Rattus norvegicus (taxid:10116)	Rat, brown rat, rats	Escherichia coli (taxid:562)
	gene: Glur2, Gria2 expression_system_strain: Origami B expression_system_vector_type: PLASMID expression_system_plasmid: pET-22b(+)

Authors :

Krintel, C., Frydenvang, K., Harpsoe, K., Gajhede, M., Kastrup, J.S.

Keywords :

AMPA receptor ligand-binding domain, GLUA2 S1S2J-L483Y-N754S, CX516, ALLOSTERIC MODULATION, MEMBRANE PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.000 Å )

Citation :

Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

Krintel, C.,Harpsoe, K.,Zachariassen, L.G. et al.
(2013) Acta Crystallogr.,Sect.D 69 : 1645 - 1652

Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2.

Krintel, C.,Frydenvang, K.,Olsen, L. et al.
(2012) Biochem.J. 441 : 173 - 178

Mechanism of positive allosteric modulators acting on AMPA receptors.

Jin, R.,Clark, S.,Weeks, A.M. et al.
(2005) J.Neurosci. 25 : 9027 - 9036

PDB ID: 4IY5