Brand  (β version)

PDB ID: 4IY5

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
CX5 Piperidin-1-yl(quinoxalin-6-yl)methanone PoSSuM
GLU Glutamic acid PoSSuM
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4IY5   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Crystal structure of the glua2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and CX516 at 2.0 A resolution
Release Data : 2013-10-09
Compound :
mol_id molecule chains synonym
1 Glutamate receptor 2 A,B GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2
fragment: Ligand binding domain, UNP RESIDUES 413-527, 653-796
mutation: L94Y, N242S
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Rat, brown rat, rats Escherichia coli  (taxid:562)
gene: Glur2, Gria2
expression_system_strain: Origami B
expression_system_vector_type: PLASMID
expression_system_plasmid: pET-22b(+)
Authors : Krintel, C., Frydenvang, K., Harpsoe, K., Gajhede, M., Kastrup, J.S.
Keywords : AMPA receptor ligand-binding domain, GLUA2 S1S2J-L483Y-N754S, CX516, ALLOSTERIC MODULATION, MEMBRANE PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

Krintel, C.,Harpsoe, K.,Zachariassen, L.G.  et al.
(2013)  Acta Crystallogr.,Sect.D  69 : 1645 - 1652

PubMed: 23999288
DOI: 10.1107/S0907444913011839

Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2.

Krintel, C.,Frydenvang, K.,Olsen, L.  et al.
(2012)  Biochem.J.  441 : 173 - 178

PubMed: 21895609
DOI: 10.1042/BJ20111221

Mechanism of positive allosteric modulators acting on AMPA receptors.

Jin, R.,Clark, S.,Weeks, A.M.  et al.
(2005)  J.Neurosci.  25 : 9027 - 9036

PubMed: 16192394
DOI: 10.1523/JNEUROSCI.2567-05.2005

Reaction

Chain : A, B
UniProt : P19491 (GRIA2_RAT)
Reaction: EC: Evidence:
Physiological Direction:
Ca(2+)(in) = Ca(2+)(out) - PubMed:11773314, PubMed:1653450
-
Na(+)(in) = Na(+)(out) - PubMed:11773314, PubMed:1653450
-