Brand  (β version)

PDB ID: 4IU6

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Ligands
Code Name Style Show Link
CO Cobalt (II) ion PoSSuM
FZ1 4-[4-(4-methoxyphenyl)piperazin-1-yl]-2-(pyridin-2-yl)quinazoline PoSSuM
K Potassium ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4IU6   PDBj   RCSB PDB   PDBe
Header : hydrolase/hydrolase inhibitor
Title : Human Methionine Aminopeptidase in complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1
Release Data : 2013-05-01
Compound :
mol_id molecule chains synonym
1 Methionine aminopeptidase 1 A MAP 1, MetAP 1, Peptidase M 1
ec: 3.4.11.18
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: METAP1, KIAA0094
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
Authors : Gabelli, S.B., Zhang, F., Miller, M., Liu, J., Amzel, L.M.
Keywords : MetAp1, Methionine Aminopeptidase 1, Methionine Aminopeptidase, hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.9000 Å )
Citation :

Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.

Zhang, F.,Bhat, S.,Gabelli, S.B.  et al.
(2013)  J.Med.Chem.  56 : 3996 - 4016

PubMed: 23634668
DOI: 10.1021/jm400227z

Reaction

Chain : A
UniProt : P53582 (MAP11_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. 3.4.11.18 HAMAP-Rule:MF_03174, PubMed:17114291
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Cofactor: Evidence: Note:
Fe(2+) ECO:0000255 | HAMAP-Rule:MF_03174
ECO:0000255 | HAMAP-Rule:MF_03174
ECO:0000255 | HAMAP-Rule:MF_03174
ECO:0000255 | HAMAP-Rule:MF_03174
Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc