Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
CO Cobalt (II) ion
FZ1 4-[4-(4-methoxyphenyl)piperazin-1-yl]-2-(pyridin-2-yl)quinazoline
K Potassium ion
SO4 Sulfate ion
Code : 4IU6
Header : hydrolase/hydrolase inhibitor
Title : Human Methionine Aminopeptidase in complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1
Release Data : 2013-05-01
Compound :
mol_id molecule chains synonym
1 Methionine aminopeptidase 1 A MAP 1, MetAP 1, Peptidase M 1
ec: 3.4.11.18
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: METAP1, KIAA0094
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
Authors : Gabelli, S.B., Zhang, F., Miller, M., Liu, J., Amzel, L.M.
Keywords : MetAp1, Methionine Aminopeptidase 1, Methionine Aminopeptidase, hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.9000 Å )
Citation :

Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.

Zhang, F.,Bhat, S.,Gabelli, S.B.  et al.
(2013)  J.Med.Chem.  56 : 3996 - 4016

PubMed: 23634668
DOI: 10.1021/jm400227z

Chain : A
UniProt : P53582 (MAP11_HUMAN)
Reaction : Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.