Brand  (β version)

PDB ID: 4ITD

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Ligands
Code Name Style Show Link
HT 2'-(4-hydroxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-benzimidazole PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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C6G 6-(carboxymethoxy)-9-(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-9h-purin-2-amine
Glycosylation
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Structure summary

Code : 4ITD   PDBj   RCSB PDB   PDBe
Header : DNA
Title : Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation
Release Data : 2013-05-08
Compound :
mol_id molecule chains
1 DNA (5'-D(*CP*GP*CP*GP*(C6G)P*AP*TP*TP*CP*GP*CP*G)-3') A,B
Source :
mol_id organism_scientific
1
synthetic: yes
Authors : Zhang, F., Suzuki, K., Tsunoda, M., Wilkinson, O., Millington, C.L., Williams, D.M., Morishita, E.C., Takenaka, A.
Keywords : damaged DNA, O6-carboxymethylguanine, mutagenesis, DNA
Exp. method : X-RAY DIFFRACTION ( 1.94 Å )
Citation :

Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations

Zhang, F.,Tsunoda, M.,Suzuki, K.  et al.
(2013)  Nucleic Acids Res.  41 : 5524 - 5532

PubMed: 23580550
DOI: 10.1093/nar/gkt198