Brand  (β version)

PDB ID: 4IRC

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Ligands
Code Name Style Show Link
0KX 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 4IRC   PDBj   RCSB PDB   PDBe
Header : Transferase/DNA
Title : Polymerase-DNA complex
Release Data : 2013-04-10
Compound :
mol_id molecule chains
1 DNA (5'-D(*TP*CP*TP*GP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3') G,B
mol_id molecule chains
2 DNA (5'-D(*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3') H
mol_id molecule chains
3 DNA (5'-D(*CP*TP*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3') C
mol_id molecule chains synonym
4 DNA polymerase IV F,A Pol IV
ec: 2.7.7.7
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
mol_id organism_scientific
3
synthetic: yes
mol_id organism_scientific expression_system
4 Escherichia coli  (taxid:83333) Escherichia coli  (taxid:562)
strain: k12
gene: b0231, dinB, dinP, JW0221
expression_system_strain: C41DE3
Authors : Nair, D.T., Sharma, A.
Keywords : DNA Polymerase, Y-family, Transferase-DNA complex
Exp. method : X-RAY DIFFRACTION ( 2.67 Å )
Citation :

A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli.

Sharma, A.,Kottur, J.,Narayanan, N.  et al.
(2013)  Nucleic Acids Res.  41 : 5104 - 5114

PubMed: 23525461
DOI: 10.1093/nar/gkt146

Reaction

Chain : F, A
UniProt : Q47155 (DPO4_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate 2.7.7.7 -
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250
Binds 2 magnesium ions per subunit.