Het-PDB Navi2 (PDB: 4IGF)

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Ligands
Code	Name	Link
CHV	3-(4-chloro-2-hydroxyphenoxy)-7-hydroxy-2h-chromen-2-one	PoSSuM
GOL	Glycerol	PoSSuM
NAD	Nicotinamide-adenine-dinucleotide	PoSSuM
SO4	Sulfate ion	PoSSuM

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Download interaction data: 4IGF

Code :

4IGF PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR

Title :

Crystal structure of Plasmodium falciparum FabI complexed with NAD and inhibitor 3-(4-Chloro-2-hydroxyphenoxy)-7-hydroxy-2H-chromen-2-one

Release Data :

2013-11-06

Compound :

mol_id	molecule	chains
1	Enoyl-acyl carrier reductase	A,B
	ec: 1.3.1.9 fragment: C-terminal fragment, UNP residues 96-432

Source :

mol_id	organism_scientific	expression_system
1	Plasmodium falciparum (taxid:36329)	Escherichia coli (taxid:562)
	strain: 3D7 gene: PfENR, PFF0730c expression_system_strain: BL21 expression_system_vector_type: plasmid expression_system_plasmid: pET28a

Authors :

Kostrewa, D., Perozzo, R.

Keywords :

Reductase, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.300 Å )

Citation :

Design, Synthesis, and Biological and Crystallographic Evaluation of Novel Inhibitors of Plasmodium falciparum Enoyl-ACP-reductase (PfFabI)

Belluti, F.,Perozzo, R.,Lauciello, L. et al.
(2013) J.Med.Chem. 56 : 7516 - 7526

PDB ID: 4IGF