Brand  (β version)

PDB ID: 4I5X

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Ligands
Code Name Style Show Link
FLF 2-[[3-(trifluoromethyl)phenyl]amino] benzoic acid PoSSuM
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4I5X   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure Of AKR1B10 Complexed With NADP+ And Flufenamic acid
Release Data : 2013-10-23
Compound :
mol_id molecule chains synonym
1 Aldo-keto reductase family 1 member B10 A ARL-1, Aldose reductase-like, Aldose reductase-related protein, ARP, hARP, Small intestine reductase, SI reductase
ec: 1.1.1.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: AKR1B10
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET15b
Authors : Zhang, L., Zheng, X., Chen, S., Zhai, J., Zhang, H., Zhao, Y.
Keywords : TIM barrel, aldo-keto reductase, Oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 2.100 Å )
Citation :

Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111)

Zhang, L.,Zhang, H.,Zhao, Y.  et al.
(2013)  Febs Lett.  587 : 3681 - 3686

PubMed: 24100137
DOI: 10.1016/j.febslet.2013.09.031

Reaction

Chain : A
UniProt : O60218 (AK1BA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH 1.1.1.300 PubMed:12732097, PubMed:18087047
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9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH - PubMed:12732097, PubMed:18087047
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13-cis-retinol + NADP(+) = 13-cis-retinal + H(+) + NADPH - PubMed:12732097
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allyl alcohol + NADP(+) = acrolein + H(+) + NADPH 1.1.1.54 PubMed:19563777
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(E)-4-hydroxynon-2-en-1-ol + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH - PubMed:19013440
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a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + H(+) + NADPH - PubMed:19563777
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NADP(+) + prenol = 3-methyl-2-butenal + H(+) + NADPH - PubMed:19563777
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(E)-hex-2-en-1-ol + NADP(+) = (E)-hex-2-enal + H(+) + NADPH - PubMed:19563777
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(E,E)-2,4-hexadien-1-ol + NADP(+) = (E,E)-2,4-hexadienal + H(+) + NADPH - PubMed:19563777
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(E)-4-oxonon-2-en-1-ol + NADP(+) = (E)-4-oxonon-2-enal + H(+) + NADPH - PubMed:19013440
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4-methylpentan-1-ol + NADP(+) = 4-methylpentanal + H(+) + NADPH - PubMed:19013440
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