Het-PDB Navi2 (PDB: 4I5C)

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Ligands
Code	Name		Style	Show	Link
C5I	3-oxo-3-[(3r)-3-(pyrrolo[2,3-B][1,2,3]triazolo[4,5-D]pyridin-1(6h)-yl)piperidin-1-yl]propanenitrile				PoSSuM

Non-standard Residues
Code	Name	Show
PTR	O-phosphotyrosine

Glycosylation
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Download interaction data: 4I5C

Code :

4I5C PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

The Jak1 kinase domain in complex with inhibitor

Release Data :

2013-05-22

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase JAK1	A,B	Janus kinase 1, JAK-1
	ec: 2.7.10.2 fragment: Protein kinase 2 domain residues 854-1154

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: JAK1, JAK1A, JAK1B

Authors :

Fong, R., Lupardus, P.J.

Keywords :

kinase, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.10 Å )

Citation :

Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.

Hurley, C.A.,Blair, W.S.,Bull, R.J. et al.
(2013) Bioorg.Med.Chem.Lett. 23 : 3592 - 3598

Chain :

A, B

UniProt :

P23458 (JAK1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:1848670, PubMed:7615558
	-	PROSITE-ProRule:PRU10028, PubMed:1848670, PubMed:7615558

PDB ID: 4I5C