Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
C5I 3-oxo-3-[(3r)-3-(pyrrolo[2,3-B][1,2,3]triazolo[4,5-D]pyridin-1(6h)-yl)piperidin-1-yl]propanenitrile
EDO 1,2-ethanediol
Modified Residues
Code Name Link
PTR O-phosphotyrosine
Code : 4I5C
Header : TRANSFERASE
Title : The Jak1 kinase domain in complex with inhibitor
Release Data : 2013-05-22
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase JAK1 A,B Janus kinase 1, JAK-1
ec: 2.7.10.2
fragment: Protein kinase 2 domain residues 854-1154
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: JAK1, JAK1A, JAK1B
Authors : Fong, R., Lupardus, P.J.
Keywords : kinase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.

Hurley, C.A.,Blair, W.S.,Bull, R.J.  et al.
(2013)  Bioorg.Med.Chem.Lett.  23 : 3592 - 3598

PubMed: 23642482
DOI: 10.1016/j.bmcl.2013.04.018

Chain : A, B
UniProt : P23458 (JAK1_HUMAN)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.