Brand  (β version)

PDB ID: 4I0I

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Ligands
Code Name Style Show Link
957 N-[(1s,2r)-1-(3,5-difluorobenzyl)-3-({1-[4-(2,2-dimethylpropyl)thiophen-2-yl]cyclopropyl}amino)-2-hydroxypropyl]acetamide PoSSuM
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Structure summary

Code : 4I0I   PDBj   RCSB PDB   PDBe
Header : hydrolase/hydrolase inhibitor
Title : SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors
Release Data : 2013-11-20
Compound :
mol_id molecule chains synonym
1 Beta-secretase 1 A,B,C Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2
ec: 3.4.23.46
fragment: unp residues 57-453
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: BACE1, BACE, KIAA1149
Authors : Yao, N., Brecht, E.
Keywords : BACE, Aspartic protease, hydrolysis, hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors

Mondal, K.,Regnstrom, K.,Morishige, W.  et al.
To be Published 

Reaction

Chain : A, B, C
UniProt : P56817 (BACE1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|- Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein. 3.4.23.46 PubMed:10677483
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