Brand  (β version)

PDB ID: 4HYT

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
OBN Ouabain PoSSuM
CLR Cholesterol PoSSuM
1AT Beta-D-fructofuranosyl 6-O-decanoyl-alpha-D-glucopyranoside PoSSuM
1DS 1-O-decanoyl-beta-D-tagatofuranosyl beta-D-allopyranoside PoSSuM
17F O-[(S)-({(2r)-2,3-bis[(9z)-octadec-9-enoyloxy]propyl}oxy)(hydroxy)phosphoryl]-L-serine PoSSuM
CE1 O-dodecanyl octaethylene glycol PoSSuM
Non-standard Residues
Code Name Show
PHD Aspartyl phosphate
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 4HYT   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/MEMBRANE PROTEIN
Title : Na,K-ATPase in the E2P state with bound ouabain and Mg2+ in the cation-binding site
Release Data : 2013-06-26
Compound :
mol_id molecule chains synonym
1 Sodium/potassium-transporting ATPase subunit alpha-1 A,C Na(+)/K(+) ATPase alpha-1 subunit, Sodium pump subunit alpha-1
ec: 3.6.3.9
mol_id molecule chains synonym
2 Sodium/potassium-transporting ATPase subunit beta-1 B,D Sodium/potassium-dependent ATPase subunit beta-1
mol_id molecule chains
3 Na+/K+ ATPase gamma subunit transcript variant a G,E
Source :
mol_id organism_scientific organism_common
1 Sus scrofa  (taxid:9823) Pig
mol_id organism_scientific organism_common
2 Sus scrofa  (taxid:9823) Pig
mol_id organism_scientific organism_common
3 Sus scrofa  (taxid:9823) Pig
Authors : Laursen, M., Yatime, L., Nissen, P., Fedosova, N.U.
Keywords : membrane transporter, HYDROLASE-MEMBRANE PROTEIN complex
Exp. method : X-RAY DIFFRACTION ( 3.404 Å )
Citation :

Crystal structure of the high-affinity Na+,K+-ATPase-ouabain complex with Mg2+ bound in the cation binding site.

Laursen, M.,Yatime, L.,Nissen, P.  et al.
(2013)  Proc.Natl.Acad.Sci.USA  110 : 10958 - 10963

PubMed: 23776223
DOI: 10.1073/pnas.1222308110

Reaction

Chain : A, C
UniProt : P05024 (AT1A1_PIG)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate 7.2.2.13 PubMed:18075585
-
Chain : B, D
UniProt : P05027 (AT1B1_PIG)
Reaction : -
Chain : G, E
UniProt : Q58K79 (Q58K79_PIG)
Reaction : -