Het-PDB Navi2 (PDB: 4HY6)

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Ligands
Code	Name		Style	Show	Link
FJ1	6,6-dimethyl-3-(trifluoromethyl)-1,5,6,7-tetrahydro-4h-indazol-4-one				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4HY6

Code :

4HY6 PDBj RCSB PDB PDBe

Header :

Chaperone/Chaperone Inhibitor

Title :

Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1

Release Data :

2013-05-15

Compound :

mol_id	molecule	chains	synonym
1	Heat shock protein HSP 90-alpha	A	Heat shock 86 kDa, HSP 86, HSP86, Renal carcinoma antigen NY-REN-38
	fragment: N-Terminal domain, UNP residues 9-236

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: HSP90AA1 expression_system_strain: BL21 expression_system_vector_type: PLASMID expression_system_plasmid: PET28A

Authors :

Yang, M., Li, J., He, J.H.

Keywords :

ATP Binding, molecularchaperone, inhibitor, Rossmann Fold, molecular chaperone, ATP hydrolysis, Chaperone-Chaperone Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.649 Å )

Citation :

Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1

Yang, M.,Li, J.,He, J.H.
to be published

Chain :

UniProt :

P07900 (HS90A_HUMAN)

PDB ID: 4HY6