Brand  (β version)

PDB ID: 4HUA

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Ligands
Code Name Style Show Link
CU Copper (II) ion PoSSuM
Non-standard Residues
Code Name Show
FP9 (4r)-4-fluoro-L-proline
Glycosylation
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Modification
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Structure summary

Code : 4HUA   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : E. coli thioredoxin variant with (4R)-FluoroPro76 as single proline residue
Release Data : 2013-05-29
Compound :
mol_id molecule chains
1 Thioredoxin-1 A
mutation: P34A, P40A, P64A, P68A
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:83333) Escherichia coli  (taxid:562)
strain: K-12
gene: trxA, fipA, tsnC
expression_system_strain: JM83
expression_system_vector_type: plasmid
expression_system_plasmid: pTrx1P
Authors : Scharer, M.A., Rubini, M., Capitani, G., Glockshuber, R.
Keywords : 4r-fluoroproline, cisproline, thioredoxin fold, protein disulfide oxidoreductase activity, oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 1.1000 Å )
Citation :

(4R)- and (4S)-Fluoroproline in the Conserved cis-Prolyl Peptide Bond of the Thioredoxin Fold: Tertiary Structure Context Dictates Ring Puckering.

Rubini, M.,Scharer, M.A.,Capitani, G.  et al.
(2013)  Chembiochem  14 : 1053 - 1057

PubMed: 23712956
DOI: 10.1002/cbic.201300178

Reaction

Chain : A
UniProt : P0AA25 (THIO_ECOLI)
Reaction : -