Brand  (β version)

PDB ID: 4HN2

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Ligands
Code Name Style Show Link
0EJ (2-oxo-2-{[(1s,2r,3s,4s,5r,6s)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]oxy}ethyl)phosphonic acid PoSSuM
ANP Phosphoaminophosphonic acid-adenylate ester PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4HN2   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP and a substrate analog 5PA-IP5
Release Data : 2012-10-31
Compound :
mol_id molecule chains synonym
1 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 A Diphosphoinositol pentakisphosphate kinase 2, Histidine acid phosphatase domain-containing protein 1, InsP6 and PP-IP5 kinase 2, VIP1 homolog 2, hsVIP2
ec: 2.7.4.21, 2.7.4.24
fragment: ATP-grasp Kinase domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HISPPD1, KIAA0433, PPIP5K2, VIP2
expression_system_strain: Arctic Express (DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pDest566
Authors : Wang, H.
Keywords : ATP-grasp Fold, Inositol Pyrophosphate Kinase, Phosphoryl Transferase, Pyrophosphate Analog, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP(5) kinase.

Riley, A.M.,Wang, H.,Weaver, J.D.  et al.
(2012)  Chem.Commun.(Camb.)  48 : 11292 - 11294

PubMed: 23032903
DOI: 10.1039/c2cc36044f

Reaction

Chain : A
UniProt : O43314 (VIP2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo- inositol 2,3,4,5,6-pentakisphosphate + ADP 2.7.4.24 PubMed:21222653, PubMed:29590114
left-to-right PubMed:29590114
5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP 2.7.4.24 PubMed:21222653, PubMed:22119861, PubMed:29590114
left-to-right PubMed:22119861