Brand  (β version)

PDB ID: 4HKY

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Ligands
Code Name Style Show Link
FPM (5r,6s)-6-(1-hydroxyethyl)-7-oxo-3-[(2r)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid PoSSuM
SFR (2r)-2-[(1s,2r)-1-carboxy-2-hydroxypropyl]-5-[(2r)-oxolan-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylic acid PoSSuM
CD Cadmium ion PoSSuM
CL Chloride ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4HKY   PDBj   RCSB PDB   PDBe
Header : Hydrolase/Antibiotic
Title : New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Faropenem
Release Data : 2013-01-23
Compound :
mol_id molecule chains synonym
1 Beta-lactamase NDM-1 A,B NDM-1, Metallo-beta-lactamase NDM-1
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 Klebsiella pneumoniae  (taxid:573) Escherichia coli  (taxid:511693)
gene: blaNDM-1
expression_system_strain: BL21 magic
expression_system_vector_type: plasmid
expression_system_plasmid: pMCSG7
Authors : Kim, Y., Tesar, C., Jedrzejczak, R., Babnigg, J., Mire, J., Sacchettini, J., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI)
Keywords : Structural Genomics, PSI-2, Protein Structure Initiative, Midwest Center for Structural Genomics, MCSG, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors, MTBI, alpha-beta-beta-alpha sandwich, hydrolase, PSI-Biology, Hydrolase-Antibiotic complex
Exp. method : X-RAY DIFFRACTION ( 2.004 Å )
Citation :

New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Faropenem

Kim, Y.,Tesar, C.,Jedrzejczak, R.  et al.
To be Published 

Reaction

Chain : A, B
UniProt : C7C422 (BLAN1_KLEPN)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PubMed:19770275
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