Het-PDB Navi2 (PDB: 4HDA)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
ZN	Zinc ion				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 4HDA

Code :

4HDA PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE ACTIVATOR

Title :

Crystal structure of human Sirt5 in complex with Fluor-de-Lys peptide and resveratrol

Release Data :

2012-12-05

Compound :

mol_id	molecule	chains	synonym
1	NAD-dependent protein deacylase sirtuin-5, mitochondrial	A,B	Regulatory protein SIR2 homolog 5, SIR2-like protein 5
	ec: 3.5.1.- fragment: UNP residues 34-302

mol_id	molecule	chains
2	Fluor-de-Lys peptide	F

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: SIR2L5, SIRT5 expression_system_strain: BL21 (DE3) Rosetta2 expression_system_vector_type: plasmid expression_system_plasmid: pET151/D-TOPO

mol_id	organism_scientific
2
	synthetic: yes other_details: coumarin-modified tetra peptide

Authors :

Gertz, M., Steegborn, C.

Keywords :

NAD-dependent deacetylase, Sirtuin, mitochondrial, activator complex, resveratrol, HYDROLASE-HYDROLASE ACTIVATOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.6010 Å )

Citation :

A molecular mechanism for direct sirtuin activation by resveratrol.

Gertz, M.,Nguyen, G.T.,Fischer, F. et al.
(2012) Plos One 7 : e49761 - e49761

Chain :

A, B

UniProt :

Q9NXA8 (SIR5_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) = 2''-O-malonyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide	-	HAMAP-Rule:MF_03160, PubMed:22076378
	-	HAMAP-Rule:MF_03160, PubMed:22076378
H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O- succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide	-	HAMAP-Rule:MF_03160, PubMed:22076378, PubMed:29180469
	-	HAMAP-Rule:MF_03160, PubMed:22076378, PubMed:29180469
H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O- glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide	-	HAMAP-Rule:MF_03160, PubMed:24703693
	-	HAMAP-Rule:MF_03160, PubMed:24703693

PDB ID: 4HDA