Brand  (β version)

PDB ID: 4HBM

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Ligands
Code Name Style Show Link
0Y7 {(3r,5r,6s)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2s)-1-hydroxybutan-2-yl]-2-oxopiperidin-3-yl}acetic acid PoSSuM
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Structure summary

Code : 4HBM   PDBj   RCSB PDB   PDBe
Header : ligase/ligase inhibitor
Title : Ordering of the N Terminus of Human MDM2 by Small Molecule Inhibitors
Release Data : 2012-10-17
Compound :
mol_id molecule chains synonym
1 E3 ubiquitin-protein ligase Mdm2 A,B,C,D,E,F,G,H Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2
ec: 6.3.2.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MDM2
Authors : Huang, X.
Keywords : MDM2, p53, protein protein interaction, inhibitor, ligase-ligase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Ordering of the N-terminus of human MDM2 by small molecule inhibitors.

Michelsen, K.,Jordan, J.B.,Lewis, J.  et al.
(2012)  J.Am.Chem.Soc.  134 : 17059 - 17067

PubMed: 22991965
DOI: 10.1021/ja305839b

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : Q00987 (MDM2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. 2.3.2.27 PubMed:12821780
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