Brand  (β version)

PDB ID: 4H52

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
FSI 5-acetamido-3,5-dideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 4H52   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Wild-type influenza N2 neuraminidase covalent complex with 3-fluoro-Neu5Ac
Release Data : 2013-02-20
Compound :
mol_id molecule chains
1 Neuraminidase A,B
fragment: ECTODOMAIN, UNP residues 82-469
Source :
mol_id organism_scientific expression_system
1 Influenza A virus  (taxid:382827) Spodoptera frugiperda  (taxid:7108)
strain: A/RI/5+/1957(H2N2)
expression_system_cell_line: SF9
expression_system_vector_type: baculovirus
Authors : Vavricka, C.J., Liu, Y., Kiyota, H., Sriwilaijaroen, N., Qi, J., Tanaka, K., Wu, Y., Li, Q., Li, Y., Yan, J., Suzuki, Y., Gao, G.F.
Keywords : NEURAMINIDASE, INFLUENZA SURFACE GLYCOPROTEIN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.803 Å )
Citation :

Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors

Vavricka, C.J.,Liu, Y.,Kiyota, H.  et al.
(2013)  Nat Commun  4 : 1491 - 1491

PubMed: 23422659
DOI: 10.1038/ncomms2487

Reaction

Chain : A, B
UniProt : Q194T1 (Q194T1_9INFA)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha- (2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. 3.2.1.18 HAMAP- Rule:MF_04071, RuleBase:RU361252
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