Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0YV 2,2'-{benzene-1,3-diylbis[ethyne-2,1-diyl(5-bromobenzene-3,1-diyl)]}diethanamine
Code : 4H2M
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1408
Release Data : 2012-12-19
Compound :
mol_id molecule chains synonym
1 Undecaprenyl pyrophosphate synthase A,B UPP synthase, Di-trans,poly-cis-decaprenylcistransferase, Ditrans,polycis-undecaprenyl-diphosphate synthase, Undecaprenyl diphosphate synthase, UDS
ec: 2.5.1.31
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: uppS, ispU, rth, yaeS, b0174, JW0169
Authors : Zhu, W., Oldfield, E.
Keywords : prenyl transferase inhibitor complex, alpha-helix, prenyl transferase, cell wall biosynthesis, farnesyl diphosphate binding, isopentenyl diphosphate binding, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.780 Å )
Citation :

Antibacterial drug leads targeting isoprenoid biosynthesis.

Zhu, W.,Zhang, Y.,Sinko, W.  et al.
(2013)  Proc.Natl.Acad.Sci.USA  110 : 123 - 128

PubMed: 23248302
DOI: 10.1073/pnas.1219899110

Chain : A, B
UniProt : P60472 (UPPS_ECOLI)
Reaction : (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.