Brand  (β version)

PDB ID: 4H2H

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Ligands
Code Name Style Show Link
0XW (2s,4r)-4-hydroxy-1,1-dimethylpyrrolidinium-2-carboxylate PoSSuM
IOD Iodide ion PoSSuM
MG Magnesium ion PoSSuM
MPD (4s)-2-methyl-2,4-pentanediol PoSSuM
NI Nickel (II) ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4H2H   PDBj   RCSB PDB   PDBe
Header : ISOMERASE
Title : Crystal structure of an enolase (mandalate racemase subgroup, target EFI-502101) from Pelagibaca bermudensis htcc2601, with bound Mg and L-4-hydroxyproline betaine (betonicine)
Release Data : 2012-10-10
Compound :
mol_id molecule chains
1 Mandelate racemase/muconate lactonizing enzyme A,B,C,D,E,F,G,H
Source :
mol_id organism_scientific expression_system
1 Pelagibaca bermudensis  (taxid:314265) Escherichia coli  (taxid:469008)
strain: HTCC2601
gene: R2601_01638
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET
Authors : Vetting, M.W., Morisco, L.L., Wasserman, S.R., Sojitra, S., Imker, H.J., Gerlt, J.A., Almo, S.C., Enzyme Function Initiative (EFI)
Keywords : Enolase, mandelate racemase subgroup, enzyme function initiative, EFI, Structural Genomics, ISOMERASE
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

Discovery of new enzymes and metabolic pathways by using structure and genome context.

Zhao, S.,Kumar, R.,Sakai, A.  et al.
(2013)  Nature  502 : 698 - 702

PubMed: 24056934
DOI: 10.1038/nature12576

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : Q0FPQ4 (HPBD_SALBH)
Reaction: EC: Evidence:
Physiological Direction:
trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine 5.1.1.22 PubMed:24056934
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L-proline betaine = D-proline betaine 5.1.1.22 PubMed:24056934
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