Brand  (β version)

PDB ID: 4H1N

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Ligands
Code Name Style Show Link
CGE Clopidogrel PoSSuM
CM5 5-cyclohexyl-1-pentyl-beta-D-maltoside PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4H1N   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of P450 2B4 F297A Mutant in Complex with Anti-platelet Drug Clopidogrel
Release Data : 2013-01-16
Compound :
mol_id molecule chains synonym
1 Cytochrome P450 2B4 A CYPIIB4, Cytochrome P450 isozyme 2, Cytochrome P450 LM2, Cytochrome P450 type B0, Cytochrome P450 type B1
ec: 1.14.14.1
mutation: H226Y, F297A
Source :
mol_id organism_scientific organism_common expression_system
1 Oryctolagus cuniculus  (taxid:9986) European rabbit,Japanese white rabbit,domestic rabbit,rabbits Escherichia coli  (taxid:562)
gene: CYP2B4, CYP2B6
expression_system_strain: TOPP3
expression_system_vector_type: Plasmid
expression_system_plasmid: pKK
Authors : Shah, M.B., Jang, H.H., Stout, C.D., Halpert, J.R.
Keywords : P450, cytochrome P450 2B4, monooxygenase, oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 2.99 Å )
Citation :

X-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: Insights into compensatory rearrangements of the binding pocket.

Shah, M.B.,Jang, H.H.,Zhang, Q.  et al.
(2013)  Arch.Biochem.Biophys.  530 : 64 - 72

PubMed: 23296089
DOI: 10.1016/j.abb.2012.12.016

Reaction

Chain : A
UniProt : P00178 (CP2B4_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] 1.14.14.1 -
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