Brand  (β version)

PDB ID: 4H1J

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0YH 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(4-methoxy-2-methylphenyl)-1h-pyrazol-5-yl]urea PoSSuM

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Structure summary

Code : 4H1J   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of PYK2 with the pyrazole 13a
Release Data : 2012-11-28
Compound :
mol_id molecule chains synonym
1 Protein-tyrosine kinase 2-beta A PYK2, Calcium-dependent tyrosine kinase, CADTK, Calcium-regulated non-receptor proline-rich tyrosine kinase, Cell adhesion kinase beta, CAK-beta, CAKB, Focal adhesion kinase 2, FADK 2, Proline-rich tyrosine kinase 2, Related adhesion focal tyrosine kinase, RAFTK
ec: 2.7.10.2
fragment: protein kinase domain (UNP residues 416-692)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: PTK2B, FAK2, PYK2, RAFTK
expression_system_common: Fall armyworm
Authors : Han, S.
Keywords : kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.

Bhattacharya, S.K.,Aspnes, G.E.,Bagley, S.W.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 7523 - 7529

PubMed: 23153798
DOI: 10.1016/j.bmcl.2012.10.039

Reaction

Chain : A
UniProt : Q14289 (FAK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:15050747, PubMed:15166227, PubMed:18339875, PubMed:18951788, PubMed:19428251, PubMed:19648005
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