Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0YH 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(4-methoxy-2-methylphenyl)-1h-pyrazol-5-yl]urea
Code : 4H1J
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of PYK2 with the pyrazole 13a
Release Data : 2012-11-28
Compound :
mol_id molecule chains synonym
1 Protein-tyrosine kinase 2-beta A PYK2, Calcium-dependent tyrosine kinase, CADTK, Calcium-regulated non-receptor proline-rich tyrosine kinase, Cell adhesion kinase beta, CAK-beta, CAKB, Focal adhesion kinase 2, FADK 2, Proline-rich tyrosine kinase 2, Related adhesion focal tyrosine kinase, RAFTK
ec: 2.7.10.2
fragment: protein kinase domain (UNP residues 416-692)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: PTK2B, FAK2, PYK2, RAFTK
expression_system_common: Fall armyworm
Authors : Han, S.
Keywords : kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.

Bhattacharya, S.K.,Aspnes, G.E.,Bagley, S.W.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 7523 - 7529

PubMed: 23153798
DOI: 10.1016/j.bmcl.2012.10.039

Chain : A
UniProt : Q14289 (FAK2_HUMAN)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.