Brand  (β version)

PDB ID: 4GV1

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Ligands
Code Name Style Show Link
0XZ 4-amino-N-[(1s)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7h-pyrrolo[2,3-D]pyrimidin-4-yl)piperidine-4-carboxamide PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
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TPO Phosphothreonine
Glycosylation
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Modification
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Structure summary

Code : 4GV1   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : PKB alpha in complex with AZD5363
Release Data : 2013-02-27
Compound :
mol_id molecule chains synonym
1 RAC-alpha serine/threonine-protein kinase A Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha
ec: 2.7.11.1
fragment: kinase domain (UNP residues 144-480)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: AKT1, PKB, RAC
expression_system_common: Fall armyworm
Authors : Addie, M., Ballard, P., Bird, G., Buttar, D., Currie, G., Davies, B., Debreczeni, J., Dry, H., Dudley, P., Greenwood, R., Hatter, G., Jestel, A., Johnson, P.D., Kettle, J.G., Lane, C., Lamont, G., Leach, A., Luke, R.W.A., Ogilvie, D., Page, K., Pass, M., Steinbacher, S., Steuber, H., Pearson, S., Ruston, L.
Keywords : protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.49 Å )
Citation :

Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases.

Addie, M.,Ballard, P.,Buttar, D.  et al.
(2013)  J.Med.Chem.  56 : 2059 - 2073

PubMed: 23394218
DOI: 10.1021/jm301762v

Reaction

Chain : A
UniProt : P31749 (AKT1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:12172553, PubMed:15861136, PubMed:16139227, PubMed:1718748, PubMed:1851997, PubMed:26440888, PubMed:31548394, PubMed:32322062, PubMed:33594058
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:12172553, PubMed:16139227, PubMed:1718748, PubMed:1851997
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