Brand  (β version)

PDB ID: 4GTA

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
FFO N-[4-({[(6s)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid PoSSuM
UMP 2'-deoxyuridine 5'-monophosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4GTA   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : T. Maritima FDTS with FAD, dUMP, and Folinic Acid
Release Data : 2012-10-17
Compound :
mol_id molecule chains synonym
1 Thymidylate synthase thyX A TS, TSase
ec: 2.1.1.148
Source :
mol_id organism_scientific expression_system
1 Thermotoga maritima  (taxid:243274) Escherichia coli  (taxid:562)
strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099
gene: thyX, thy1, TM_0449
expression_system_vector_type: Plasmid
Authors : Mathews, I.I., Lesley, S.A., Kohen, A.
Keywords : Flavin-dependent thymidylate synthase, TM0449, Folinic Acid, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.50 Å )
Citation :

Folate binding site of flavin-dependent thymidylate synthase.

Koehn, E.M.,Perissinotti, L.L.,Moghram, S.  et al.
(2012)  Proc.Natl.Acad.Sci.USA  109 : 15722 - 15727

PubMed: 23019356
DOI: 10.1073/pnas.1206077109

Reaction

Chain : A
UniProt : Q9WYT0 (THYX_THEMA)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+) 2.1.1.148 PubMed:12791256, PubMed:19370033
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dUMP + formaldehyde + H(+) + NADPH = dTMP + H2O + NADP(+) - PubMed:34315871
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