Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0Y5 4-{[(3s)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)piperidin-1-yl]methyl}-2-[3-(trifluoromethyl)phenoxy]benzoic acid
Code : 4GSY
Header : Transferase/Transferase inhibitor
Title : Crystal structure of thymidylate kinase from Staphylococcus aureus bound to inhibitor.
Release Data : 2012-10-24
Compound :
mol_id molecule chains synonym
1 Thymidylate kinase A,B dTMP kinase
ec: 2.7.4.9
fragment: Thymidylate Kinase
Source :
mol_id organism_scientific expression_system
1 Staphylococcus aureus subsp. aureus  (taxid:158879) Escherichia coli  (taxid:562)
strain: MRSA252
gene: SA0440, SAR0483, tmk
Authors : Larsen, N.A., Olivier, N.B.
Keywords : Transferase, nucleotide binding, thymidylate kinase activity, ATP binding, kinase activity, transferase activity, Transferase-Transferase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.71 Å )
Citation :

Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK).

Martinez-Botella, G.,Breen, J.N.,Duffy, J.E.  et al.
(2012)  J.Med.Chem.  55 : 10010 - 10021

PubMed: 23043329
DOI: 10.1021/jm3011806

Chain : A, B
UniProt : P65249 (KTHY_STAAN)
Reaction : ATP + dTMP = ADP + dTDP.