Het-PDB Navi2 (PDB: 4GQB)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
0XU	(2s,5s,6e)-2,5-diamino-6-[(3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxydihydrofuran-2(3h)-ylidene]hexanoic acid				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
ACE	Acetyl group

Download interaction data: 4GQB

Code :

4GQB PDBj RCSB PDB PDBe

Header :

TRANSFERASE/PROTEIN BINDING

Title :

Crystal Structure of the human PRMT5:MEP50 Complex

Release Data :

2012-10-17

Compound :

mol_id	molecule	chains	synonym
1	Protein arginine N-methyltransferase 5	A	72 kDa ICln-binding protein, Histone-arginine N-methyltransferase PRMT5, Jak-binding protein 1, Shk1 kinase-binding protein 1 homolog, SKB1 homolog, SKB1Hs, Protein arginine N-methyltransferase 5, N-terminally processed
	ec: 2.1.1.-, 2.1.1.125

mol_id	molecule	chains	synonym
2	Methylosome protein 50	B	MEP-50, Androgen receptor cofactor p44, WD repeat-containing protein 77, p44/Mep50

mol_id	molecule	chains
3	Histone H4 peptide	C

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: PRMT5, HRMT1L5, IBP72, JBP1, SKB1

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: WDR77, MEP50, HKMT1069, Nbla10071

mol_id	organism_scientific	organism_common
3	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Antonysamy, S., Bonday, Z., Campbell, R., Doyle, B., Druzina, Z., Gheyi, T., Han, B., Jungheim, L.N., Qian, Y., Rauch, C., Russell, M., Sauder, J.M., Wasserman, S.R., Weichert, K., Willard, F.S., Zhang, A., Emtage, S.

Keywords :

TIM BARREL, BETA-PROPELLER, METHYLTRANSFERASE, METHYLATION, TRANSFERASE-PROTEIN BINDING complex

Exp. method :

X-RAY DIFFRACTION ( 2.06 Å )

Citation :

Crystal structure of the human PRMT5:MEP50 complex.

Antonysamy, S.,Bonday, Z.,Campbell, R.M. et al.
(2012) Proc.Natl.Acad.Sci.USA 109 : 17960 - 17965

PubMed: 23071334
DOI: 10.1073/pnas.1209814109

Chain :

UniProt :

O14744 (ANM5_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L- homocysteine	2.1.1.320	PubMed:19011621, PubMed:21081503, PubMed:23071334
	-	PubMed:19011621, PubMed:21081503, PubMed:23071334

Chain :	B
UniProt :	Q9BQA1 (MEP50_HUMAN)
Reaction :	-

Chain :	C
UniProt :	P62805 (H4_HUMAN)
Reaction :	-

PDB ID: 4GQB

Hetero Atom Contents

Structure summary

Reaction