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Ligands
Code Name Style Show Link
0RT 4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]-6-(2,2,2-trifluoroethyl)thieno[2,3-D]pyrimidine
DMS Dimethyl sulfoxide
EPE 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid
PE4 2-{2-[2-(2-{2-[2-(2-ethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethanol
SO4 Sulfate ion
UNX Unknown atom or ion
Non-standard Residues
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Code : 4GQ4   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION/TRANSCRIPTION inhibitor
Title : Human menin with bound inhibitor MI-2-2
Release Data : 2012-09-19
Compound :
mol_id molecule chains
1 Menin A
mutation: a541t
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MEN1, SCG2
Authors : Shi, A., Murai, M.J., He, S., Lund, G.L., Hartley, T., Purohit, T., Reddy, G., Chruszcz, M., Grembecka, J., Cierpicki, T.
Keywords : Tumor Suppressor, Nucleus, TRANSCRIPTION-TRANSCRIPTION inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.27 Å )
Citation :

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.

Shi, A.,Murai, M.J.,He, S.  et al.
(2012)  Blood  120 : 4461 - 4469

PubMed: 22936661
DOI: 10.1182/blood-2012-05-429274

Chain : A
UniProt : O00255 (MEN1_HUMAN)
Reaction : -