Het-PDB Navi2 (PDB: 4GMY)

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Ligands
Code	Name		Style	Show	Link
0X5	2,6-dichloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide				PoSSuM

Non-standard Residues
Code	Name	Show
PTR	O-phosphotyrosine

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 4GMY

Code :

4GMY PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

JAK2 kinase (JH1 domain) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE

Release Data :

2013-06-19

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase JAK2	A	Janus kinase 2, JAK-2
	ec: 2.7.10.2 fragment: JH1 domain, UNP residues 833-1132

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: JAK2 expression_system_common: Fall armyworm expression_system_vector_type: plasmid

Authors :

Murray, J.M., Shia, S.

Keywords :

JAK2, JH1 kinase domain, Tyrosine kinase, phosphotransferase, phosphorylation, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.4030 Å )

Citation :

Lead identification of novel and selective TYK2 inhibitors.

Liang, J.,Tsui, V.,Van Abbema, A. et al.
(2013) Eur.J.Med.Chem. 67 : 175 - 187

Chain :

UniProt :

O60674 (JAK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:15690087, PubMed:16174768, PubMed:7615558, PubMed:9618263
	-
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000305	Mn(2+) was used in the in vitro kinase assay but Mg(2+) is likely to be the in vivo cofactor.

PDB ID: 4GMY