Het-PDB Navi2 (PDB: 4GM8)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
0XL	2-amino-2-ethylbutanoic acid
AC5	1-aminocyclopentanecarboxylic acid

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
ALQ	2-methyl-propionic acid
0XN	1,1-bis(4-fluorophenyl)methanamine

Download interaction data: 4GM8

Code :

4GM8 PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION/TRANSCRIPTION INHIBITOR

Title :

Crystal structure of human WD repeat domain 5 with compound MM-102

Release Data :

2013-07-31

Compound :

mol_id	molecule	chains	synonym
1	WD repeat-containing protein 5	A,B,C,D	WDR5, BMP2-induced 3-kb gene protein
	fragment: UNP residues 22-334

mol_id	molecule	chains
2	MM-102	E,F,G,H

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: WDR5, BIG3 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: PET28b-sumo

mol_id	organism_scientific
2
	synthetic: yes

Authors :

Karatas, H., Townsend, E.C., Chen, Y., Bernard, D., Cao, F., Liu, L., Lei, M., Dou, Y., Wang, S.

Keywords :

MLL1, histone methyltransferase, WD40, TRANSCRIPTION-TRANSCRIPTION INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.601 Å )

Citation :

High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.

Karatas, H.,Townsend, E.C.,Cao, F. et al.
(2013) J.Am.Chem.Soc. 135 : 669 - 682

PDB ID: 4GM8