Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0XT 7-methoxy-6-methylpteridine-2,4-diamine
NMN Beta-nicotinamide ribose monophosphate
SO4 Sulfate ion
Code : 4GLW
Header : LIGASE/LIGASE INHIBITOR
Title : DNA ligase A in complex with inhibitor
Release Data : 2012-10-10
Compound :
mol_id molecule chains synonym
1 DNA ligase A,B Polydeoxyribonucleotide synthase [NAD(+)]
ec: 6.5.1.2
Source :
mol_id organism_scientific expression_system
1 Streptococcus pneumoniae  (taxid:488223) Escherichia coli  (taxid:562)
strain: P1031
gene: ligA, SPP_1122
Authors : Prade, L., Lange, R., Tidten-Luksch, N., Chambovey, A.
Keywords : DNA ligase A, inhibitor, LIGASE-LIGASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2 Å )
Citation :

Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.

Surivet, J.P.,Lange, R.,Hubschwerlen, C.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 6705 - 6711

PubMed: 23006603
DOI: 10.1016/j.bmcl.2012.08.094

Chain : A, B
UniProt : C1CKI0 (DNLJ_STRZP)
Reaction : NAD(+) + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + beta-nicotinamide D-nucleotide.