Brand  (β version)

PDB ID: 4GLW

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Ligands
Code Name Style Show Link
0XT 7-methoxy-6-methylpteridine-2,4-diamine PoSSuM
NMN Beta-nicotinamide ribose monophosphate PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4GLW   PDBj   RCSB PDB   PDBe
Header : LIGASE/LIGASE INHIBITOR
Title : DNA ligase A in complex with inhibitor
Release Data : 2012-10-10
Compound :
mol_id molecule chains synonym
1 DNA ligase A,B Polydeoxyribonucleotide synthase [NAD(+)]
ec: 6.5.1.2
Source :
mol_id organism_scientific expression_system
1 Streptococcus pneumoniae  (taxid:488223) Escherichia coli  (taxid:562)
strain: P1031
gene: ligA, SPP_1122
Authors : Prade, L., Lange, R., Tidten-Luksch, N., Chambovey, A.
Keywords : DNA ligase A, inhibitor, LIGASE-LIGASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2 Å )
Citation :

Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.

Surivet, J.P.,Lange, R.,Hubschwerlen, C.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 6705 - 6711

PubMed: 23006603
DOI: 10.1016/j.bmcl.2012.08.094

Reaction

Chain : A, B
UniProt : C1CKI0 (DNLJ_STRZP)
Reaction: EC: Evidence:
Physiological Direction:
NAD(+) + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta- nicotinamide D-nucleotide. 6.5.1.2 HAMAP-Rule:MF_01588
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Cofactor: Evidence: Note:
Mn(2+) ECO:0000255 | HAMAP-Rule:MF_01588
ECO:0000255 | HAMAP-Rule:MF_01588
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